Effect of Sucrose Ingestion at the End of a Critical Window that Increases Hypertension Susceptibility on Peripheral Mechanisms Regulating Blood Pressure in Rats. Role of Sirtuins 1 and 3

Figures

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  Figure 1. Changes in blood pressure in control and sucrose period rats. # p ≤ 0.05. n = 6, from 2 different litters. Data represent mean ± SEM, # p < 0.05.

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  Figure 2. The eNOS expression in aortas from control and sucrose period rats (SP). Data represent mean ± SEM, # p < 0.05, n = 4 (4 different homogenates from pools of 3 aortas from different rat pups and litters). A representative Western blot analysis is shown above the graph.

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  Figure 3. Insulin tolerance index in control and sucrose period rats. Measurements were taken at different times: 15, 30, 60, 90 and 120 min. 100% glucose in plasma corresponds to the value in mg/dl reported in table 2. SP, sucrose period. Data represent mean ± SEM, # p < 0.05, n = 6.

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  Figure 4. Plasma saturated fatty acids, monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA), in control and sucrose period rats (SP). Data represent mean ± SEM, # p < 0.05, n = 6.

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  Figure 5. Lipoperoxidation and total antioxidant capacity in the homogenized tissue from the thoracic aorta from control and sucrose period rats. Data represent mean ± SEM, # p < 0.05, n = 6 (6 different homogenates from pools of 3 aortas from different rat pups and litters).

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  Figure 6. Superoxide dismutase 1 and 2 expression in the homogenized tissue from the thoracic aorta from control and sucrose period (SP) rats. Data represent mean ± SEM, # p < 0.05, n = 4 (4 different homogenates from pools of 3 aortas from different rat pups and litters). A representative Western blot analysis is shown above the graphs.

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  Figure 7. Sirt 1 and Sirt 3 expression in the homogenized tissue from the thoracic aorta from control and sucrose period rats. Data represent mean ± SEM, # p < 0.05, n = 4 (4 different homogenates from pools of 3 aortas from different rat pups and litters). A representative Western blot analysis is shown above the graphs.