While alpha, beta, and gamma interferons have similar antiviral potency against HCV replicons, they exhibit distinct antiviral mechanisms and gene expression patterns.
Differences in durability and gene expression warrant caution against IFN equivalence; leaves open subtype-specific antiviral mechanisms.
A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral mechanisms were suggested following observations of striking differences between IFN-gamma and IFN-alpha/beta with respect to strength and durability of the antiviral response and the magnitude and pattern of IFN-mediated gene expression.
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Cheney et al. (2002) studied this question.
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