October 8, 2014Journal of the American Society of NephrologyOpen Access

Mediation Analysis of Aortic Stiffness and Renal Microvascular Function

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Population

367 older adults (ages 72-92 years) participating in the Age, Gene/Environment Susceptibility-Reykjavik Study

Design

Cross-sectional

Authors

TWTodd WoodardGeorgia Department of Public Health SSSigurður SigurdssonCardiac Imaging JGJohn D. GotalGeneral Nano (United States)

Discussion

Member takes

Implication

Supports pulsatility mediation of aortic stiffness-GFR relation; leaves open causal effects and clinical interventions.

Structured PICO

Population

367 older adults (ages 72-92 years) participating in the Age, Gene/Environment Susceptibility-Reykjavik Study

Outcome

Relation between aortic stiffness and GFR, and mediation by renal artery pulsatility index, renal vascular resistance, and arterial volume in the cortexsurrogate

Aortic stiffness may contribute to lower GFR by transferring excessive flow pulsatility into the susceptible renal microvasculature, leading to dynamic constriction or vessel loss.

Cite This Study

Woodard et al. (2014) studied this question.

synapsesocial.com/papers/6a83e57307bf35307a997124 https://doi.org/10.1681/asn.2014050450

View Full Paper

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Mediation Analysis of Aortic Stiffness and Renal Microvascular Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mediation Analysis of Aortic Stiffness and Renal Microvascular Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider