Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials
Why the study?
Does statin treatment reduce the risk of atrial fibrillation in patients from randomized controlled trials?
Population
139,169 patients pooled from 42 randomized controlled trials
Comparison
Statin treatment vs No statin or standard-dose statin
Design
Meta-analysis
Follow-up
Short-term and longer-term (at least 6 months)
Authors
Discussion
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Member takes
Implication
No role for statins in atrial fibrillation prevention; refutes benefit suggested by smaller short-term studies.
Structured PICO
Does statin treatment reduce the risk of atrial fibrillation in patients from randomized controlled trials?
P
Population
139,169 patients pooled from 42 randomized controlled trials (13 short-term trials [n=4,414], 22 longer-term trials [n=105,791], and 7 intensive vs standard statin trials [n=28,964])
I
Intervention
Statin treatment (any dose or high-dose intensive regimen)
C
Comparator
No statin or standard-dose statin
O
Outcome
Episode of atrial fibrillationhard clinical
A comprehensive meta-analysis of large-scale trials demonstrates that statin therapy does not reduce the risk of atrial fibrillation, refuting earlier suggestions of benefit from smaller, short-term studies.
Cite This Study
Rahimi et al. (2011) studied this question.