What question did this study set out to answer?

To compare long-term mortality in type 1 diabetes cohort participants receiving intensive versus conventional therapy to that of the general U.S. population.

July 12, 2016Diabetes CareOpen Access

Mortality in Type 1 Diabetes in the DCCT/EDIC Versus the General Population

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Implication

Long-term follow-up of a randomized trial reveals intensive glycemic control normalizes mortality in type 1 diabetes, indicating that tight glucose control prevents excess deaths.

Key Points

To compare long-term mortality in type 1 diabetes cohort participants receiving intensive versus conventional therapy to that of the general U.S. population.
Followed 1,441 participants from the DCCT trial (1983–1993, intensive vs. conventional therapy, HbA1c ~7% vs. ~9%) through the observational EDIC study for a mean of 27 years, ascertaining vital status for 97.5% of the original cohort.
Estimated expected mortality using age-, sex-, and race-specific risks from the general U.S. population and evaluated standardized mortality ratios (SMRs) using Poisson regression models.
Mortality in the intensive therapy group was nonsignificantly lower than the general population (SMR = 0.88 [95% CI 0.67, 1.16]), whereas mortality in the conventional therapy group was significantly elevated (SMR = 1.31 [95% CI 1.05, 1.65]).
Standardized mortality ratios rose significantly with increasing mean HbA1c, with a steeper increase among females than males above an HbA1c threshold of 9%.

Cite This Study

A 2016 study studied this question.

synapsesocial.com/papers/6a83ec3dd1bfc8b5a66a8876 https://doi.org/10.2337/dc15-2399

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Implication

Long-term follow-up of a randomized trial reveals intensive glycemic control normalizes mortality in type 1 diabetes, indicating that tight glucose control prevents excess deaths.

Mortality in Type 1 Diabetes in the DCCT/EDIC Versus the General Population

Discussion

Member takes

Implication

Key Points

Cite This Study

Mortality in Type 1 Diabetes in the DCCT/EDIC Versus the General Population

Discussion

Member takes

Implication

Key Points

Cite This Study

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