Reduction of Antral and Duodenal Gastrin Activity by electrical Vagal Stimulation¹

The effect of electrical vegal stimulation on the antral and duodenal gastrin activity was determined in anesthetized cats. Vagal stimulation for 1 hr at 5, 10 and 20 imp/sec reduced the antral gastrin activity to about 75, 50 and 35 per cent, respectively. Corresponding figures for figures for 2 hrs stimulation was 45, 30 and 25 percent of the activity in unstimulated cats, thus showing a further reduction. Stimulation for 4 hrs did not produce any further reduction. Vagal stimulation for 2 hrs with all 3 frequencies reduced the gastrin activity in the mucosa of the proximal duodenum to unmeasurable levels.