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Summary: A case is presented of a patient with recurrent peptic ulceration due to an excluded gastric antrum. The patient demonstrated basal hypergastrinaemia and gastric secretory studies showed a high basal acid output with only a slight increase following pentagastrin stimulation. Intravenous secretin injection caused a marked fall in serum gastrin and gastric acid output in this patient. This is in contrast to two patients with Zollinger-Ellison syndrome in whom secretin produced a rise in serum gastrin; and one of these patients who had an intact stomach, also showed a rise in gastric acid output. It is suggested that gastrin and acid output measurement after secretin injection may provide a method of differentiation of an excluded gastric antrum from the Zollinger-Ellison syndrome.
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Korman et al. (1972) studied this question.
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