Why the study?
Does the addition or maintenance of metformin improve body composition and adipocytokines in young women with ovarian hyperandrogenism treated with flutamide and ethinylestradiol-drospirenone?
Population
73 young, nonobese women with ovarian hyperandrogenism. Study A: n=31, age approximately 16 years, BMI…
Comparison
Metformin 850 mg/d added to or maintained with… vs Flutamide 62.5 mg/d and ethinylestradiol-drospire…
Design
RCT, Randomized to receive Met in addition or not; randomized for…
Follow-up
3 months
Authors
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Supports metformin inclusion in combination regimens for ovarian hyperandrogenism; extends RCT evidence on body composition.
Does the addition or maintenance of metformin improve body composition and adipocytokines in young women with ovarian hyperandrogenism treated with flutamide and ethinylestradiol-drospirenone?
Metformin is a pivotal component of combination therapy to improve body composition and adipocytokine profiles in young women with ovarian hyperandrogenism.
Ibáñez et al. (2005) studied this question.
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