The present work has demonstrated that portal blood of pig will stimulate growth of granular hepatocyte‐like cells from human embryonic liver explants in vitro. Under otherwise identical cultural conditions, this cell type do not grow when using peripheral sera from human, pig, chicken, or fetal calf. The hepatocyte‐like cells were maintained in culture for up to 110 days before signs of degeneration appeared. The results support the theory that a portal blood factor may be necessary for liver regeneration in vivo , and emphasises the importance of the local environment of specialized cells.
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Sverre O. Lie (1972) studied this question.
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