Key result
Albuminuria emerges as a clinical marker to guide HF treatment reflecting systemic and renal congestion.
Design
Review
Hypothesis-generating for systemic-renal congestion interplay in HF; leaves open optimal decongestive strategies.
The complex relationship between systemic and renal congestion in heart failure. ARNI: angiotensin receptor–neprilysin inhibitor; CVP: central venous pressure; RAASi: renin–angiotensin–aldosterone system inhibitor; SGLT2i: sodium–glucose co-transporter 2 inhibitor.
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Pugliese et al. (2022) studied this question. Albuminuria is being re-evaluated as a clinical marker to drive treatment decisions reflecting the complex relationship between systemic and renal congestion in heart failure.