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Extracts of rat skeletal muscle convert aspartate to ammonia and fumarate plus malate. The conversion is dependent on the presence of catalytic amounts of IMP, adenylosuccinate, or AMP. In addition, GTP is required as a source of energy. A GTP-regenerating system must be supplied since the accumulation of GDP inhibits the operation of the cycle. It is proposed that the purine nucleotide cycle accounts for the production of ammonia during muscular work.
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Tornheim et al. (1972) studied this question.
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