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August 1, 2006Journal of Molecular EndocrinologyOpen Access

IGF-independent effects of IGFBP-2 on the human breast cancer cell line Hs578T

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Population

Human breast cancer cell line Hs578T

Design

Preclinical

Authors

KFKlaus FrommerJustus-Liebig-Universität GießenKRKatharina ReichenmillerBSBurkhardt SchüttWestern Sydney University

Discussion

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Implication

Suggests IGFBP-2 as apoptosis target in breast cancer; hypothesis-generating and requires in vivo validation before clinical consideration.

Structured PICO

P
Population
Human breast cancer cell line Hs578T (shows no IGFBP-2 production of its own and is independent of the IGF-I receptor)
I
Intervention
Human recombinant IGFBP-2
O
Outcome
Changes in gene expression and apoptosissurrogate

IGFBP-2 promotes apoptosis and alters gene expression in human breast cancer cells independent of IGF.

Cite This Study

Frommer et al. (2006) studied this question.

synapsesocial.com/papers/6a83f49e2ccfc61f58b06dbfhttps://doi.org/10.1677/jme.1.01955
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