Association of Common Clinical Indicators with Pregnancy Outcomes in Polycystic Ovary Syndrome (PCOS)

Objective This study seeks to explore the association between common clinical indicators and pregnancy outcomes in patients with polycystic ovary syndrome (PCOS). Methods A cohort of 52 women with PCOS, 22 with isolated polycystic ovarian morphology (PCOM), 13 with isolated hyperandrogenism (HA), and 59 healthy controls was recruited from the Department of Reproductive Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, between June 2021 and September 2022. Clinical parameters including age and body mass index (BMI) were recorded, while levels of D-dimer (DD), alanine aminotransferase (ALT), aspartate transaminase (AST), creatinine (Cr), urea nitrogen (UN), fasting plasma glucose (Glu), fasting insulin (Fins), and thyroid-stimulating hormone (TSH), embryo availability rate, fertilization Rate were measured. Differences across PCOS, PCOM, and HA groups were analyzed using analysis of variance and non-parametric tests. Results (1) In the PCOS group, significant differences were observed for embryo availability rate, age, WBC, TSH, ALT, AST, MAFLD, and BARD scores (P < 0.05). (2) Embryo availability was inversely associated with age, MAFLD, BARD, Fins, TSH, and WBC, and positively associated with AST (P < 0.05). (3) Fertilization rate was negatively correlated with V-PH, CA125, granulocyte percentage, BMI, Cr, and UN/Cr (P < 0.05). (4) ROC analysis of pregnancy outcomes in PCOS patients demonstrated that age, ALT, AST, AST/ALT, Cr, UN/Cr, DD, TSH, and CA125 had areas, sensitivities, and specificities above the moving average threshold. Conclusion Endocrine profiles differ significantly among PCOS, PCOM, and HA groups, and markers such as Age, ALT, AST, AST/ALT ratio, Cr, UN/Cr, DD, TSH, and CA125 can serve as potential predictors of pregnancy outcomes in patients with PCOS.