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Summary. Extracts of splenic nerves and spleen contain small but definite amounts of adrenaline (sympathin A) in addition to noradrenaline (sympathin N) as assayed by differential tests on cat's blood pressure and hen's rectal caecum. This finding constitutes the base for a dual adrenergic nerve transmission, as indicated by remote effects after nerve stimulation (CANNON and KOSENBLUETH). Extracts of spleen contained on an average adrenaline to 7.2 per cent of the total catechols and extracts of splenic nerves significantly less, on an average 2.2 per cent. The results are in favour of the assumption that the noradrenaline in the nerves is partly methylated, this process being more intense in the peripheral parts of the nerves.
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U. S. von Euler (1949) studied this question.
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