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Studies were initiated in mice to develop a model of cell-mediated immunity to murine cytomegalovirus (MCMV). Immune interferon was produced in response to MCMV antigens in cultures of splenic lymphocytes from mice infected 7, 10, and 14 days previously. However, there was no lymphocyte transformation as measured by antigen-specific enhancement of [H]thymidine uptake. Lymphocyte transformation in response to phytohemaggluti-nin (PHA) was transiently suppressed in lymphocytes of MCMV-infected mice.
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Rytel et al. (1977) studied this question.
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