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of findings for the main comparison. Methionine and supportive treatment compared with supportive treatment for paracetamol (acetaminophen) overdose Methionine and supportive treatment compared with supportive treatment (randomised trials) for paracetamol (acetaminophen) overdose Patient or population: people with paracetamol (acetaminophen) overdose Settings: UK Intervention: methionine and supportive treatment Comparison: supportive treatment Illustrative comparative risks* (95% CI) Assumed risk Corresponding risk Outcomes Supportive treatment Methionine and supportive treatment Relative effect (95% CI) No of participants (studies) Quality of the evidence (GRADE) Comments Study population Mortality 77 per 1000 12 per 1000 (0 to 362) Peto OR 0.14 (0.00 to 6.82) 26 (1 RCT) Very low 1,2
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Chiew et al. (2018) studied this question.
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