What question did this study set out to answer?

To assess the role and mechanisms of vasomotor baroreflex responses in human skeletal muscle and skin blood vessels during prolonged mild to severe circulatory stress.

May 1, 1994Acta Physiologica Scandinavica

Skeletal muscle and skin as targets for powerful homeostatic vasomotor baroreflexes in humans during prolonged circulatory stress: a study on the innervated and nerve blocked forearm

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Why the study?

Does axillary nerve blockade alter forearm vascular resistance during lower body negative pressure in humans?

Population

Humans undergoing circulatory stress testing

Comparison

Axillary nerve blockade during lower body… vs Intact innervation during the same LBNP protocol

Design

Other

Follow-up

10 minutes

Authors

HEH. EdfeldtVäxjö Kommun JLJ. LUNDVALLMalmö University

Discussion

Member takes

Implication

Supports neural dominance in baroreflex vasoconstriction; leaves open humoral contributions in disease or chronic stress.

Key Points

To assess the role and mechanisms of vasomotor baroreflex responses in human skeletal muscle and skin blood vessels during prolonged mild to severe circulatory stress.
Monitored blood flow and vascular resistance in both innervated and axillary nerve-blocked forearms during 10-minute bouts of graded lower body negative pressure (LBNP; 15 to 85 mmHg).
Conducted experiments under thermoneutral ambient temperatures (24.8–25.7 °C) to compare intact neural pathways against localized nerve blockade.
In the intact forearm, steady-state blood flow fell by 15 ± 4%, 38 ± 5%, 63 ± 2%, and 78 ± 3% (vascular resistance increased by 27 ± 7%, 78 ± 16%, 192 ± 18%, and 387 ± 55%) at 15, 40, 70, and 85 mmHg LBNP, respectively.
Comparison between innervated and nerve-blocked arms showed that the vasoconstrictor response was neurogenic with negligible humoral contribution.
Abolition of resting vasoconstrictor tone via axillary blockade increased baseline forearm blood flow more than threefold, from 4.1 ± 0.5 to 13.1 ± 1.9 ml min⁻¹ 100 ml⁻¹.

Structured PICO

Does axillary nerve blockade alter forearm vascular resistance during lower body negative pressure in humans?

Population

Humans undergoing circulatory stress testing

Intervention

Axillary nerve blockade during lower body negative pressure (LBNP) at 15-85 mmHg for 10 min

Comparator

Intact innervation (innervated arm) during the same LBNP protocol

Outcome

Forearm flow (vascular resistance)surrogate

Sympathetic nerves elicit prominent and maintained baroreflex limb vasoconstriction in muscle and skin during circulatory stress, and reflex inhibition of resting tone allows large resistance decline.

Cite This Study

Edfeldt et al. (1994) studied this question.

synapsesocial.com/papers/6a83f8c6a3cef8348e997d02 https://doi.org/10.1111/j.1748-1716.1994.tb09721.x

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Skeletal muscle and skin as targets for powerful homeostatic vasomotor baroreflexes in humans during prolonged circulatory stress: a study on the innervated and nerve blocked forearm

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Skeletal muscle and skin as targets for powerful homeostatic vasomotor baroreflexes in humans during prolonged circulatory stress: a study on the innervated and nerve blocked forearm

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider