Why the study?
Does local tetrahydrobiopterin administration or arginase inhibition improve reflex cutaneous vasodilation in aged human skin during heat stress?
Population
22 men and women, comprising 11 young (mean age 22 ± 1 yr) and 11 older (mean age 73 ± 2 yr) subjects.
Comparison
Local intradermal microdialysis infusion of 10… vs Local intradermal microdialysis infusion of…
Design
Other
Authors
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May enhance cutaneous vasodilation during hyperthermia in older adults; leaves open systemic translation and clinical outcomes.
Does local tetrahydrobiopterin administration or arginase inhibition improve reflex cutaneous vasodilation in aged human skin during heat stress?
Local administration of tetrahydrobiopterin or arginase inhibitors augments reflex cutaneous vasodilation in aged human skin, suggesting that BH4-NOS coupling mechanisms are potential therapeutic targets for improving skin blood flow during hyperthermia in older adults.
Stanhewicz et al. (2011) studied this question.
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