Population
Normal and polycystic human ovaries (PCO) (fresh granulosa, stromal, and thecal samples)
Comparison
Incubation with LH and GH vs Normal ovaries vs polycystic ovaries; fresh vs…
Design
Preclinical
Authors
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Does not support IGF involvement in polycystic ovary disturbances; leaves open alternative mechanisms in animal models.
The study provides no evidence for a role of IGFs in the functional disturbances related to polycystic ovaries, as expression patterns did not differ from normal ovaries.
Voutilainen et al. (1996) studied this question.
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