Effects of Topical Use of β-Adrenoceptor Stimulants on Nasal Mucosa. Rhinomanometric Evaluations in Experiments with Terbutaline and KWD 2131: I. Normal Persons and Hay Fever Patients in Asymptomatic Period

The effects of nasal airway resistance of the beta-adrenoceptor stimulants terbutaline (Bricanyl) and KWD 2131 intranasally have been studied by means of posterior rhinomanometry in 16 healthy volunteers and 13 asymptomatic patients with allergic rhinitis. The study was performed as randomized, placebo-controlled, double-blind crossover trial. No obvious changes in nasal resistance were revealed. This makes the nasal muscosa a suitable organ for testing the capacity of beta-adrenoceptor stimulants to reduce the release of mediators from mast cells after allergen challenges.