Prognosis of angina with and without a diagnosis: 11 year follow up in the Whitehall II prospective cohort study
Why the study?
Does undiagnosed angina worsen prognosis (quality of life, MI, death) compared to no angina or diagnosed angina in middle-aged adults?
Population
10,308 civil servants aged 35-55 years at baseline from 20 civil service departments in London.
Comparison
Angina without a doctor's diagnosis vs Participants with a diagnosis of angina, and…
Design
Cohort
Follow-up
median 11 years
Authors
Discussion
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Member takes
Implication
Undiagnosed angina was associated with impaired function and mortality; leaves open whether detection or ECG screening improves outcomes.
Structured PICO
Does undiagnosed angina worsen prognosis (quality of life, MI, death) compared to no angina or diagnosed angina in middle-aged adults?
P
Population
10,308 civil servants aged 35-55 years at baseline from 20 civil service departments in London.
I
Intervention
Angina without a doctor's diagnosis (undiagnosed angina)
C
Comparator
Participants with a diagnosis of angina, and participants with neither angina nor myocardial infarction
O
Outcome
Recurrent reports of angina; quality of life (SF-36 physical functioning); non-fatal myocardial infarction; death from any causehard clinical
Undiagnosed angina is common and carries an adverse prognosis (impaired physical function and increased mortality with ECG abnormalities) comparable to diagnosed angina.
Cite This Study
Harry Hemingway (2003) studied this question.