Treatment of a case of primary alveolar soft part sarcoma of the lung: Case report and literature review

Figure 1.. Representative photomicrographs of the postoperative pathology in a 15-year-old male that was admitted with recurrent headaches showed the typical features of alveolar soft part sarcoma: (A and B) adenoid structures of well-defined nests of cells. The cells were large, rounded or ovoid, eosinophilic, and the nests were surrounded by fibrous septa containing distinct blood vessels (haematoxylin and eosin) and (C) positive immunohistochemical staining for transcription factor enhancer 3. Sections were counter-stained with haematoxylin (a, magnification ×100; b, magnification ×400; c, magnification ×100). The colour version of this figure is available at: http://imr.sagepub.com.

Figure 2.. Representative computed tomography (CT) images of the lungs of a 15-year-old male that was admitted with recurrent headaches: (A1 and A2) a lung CT on 25 February 2020 before treatment with anlotinib hydrochloride combined with sintilimab showed that the maximum diameter of the primary lung lesion was 6.5 cm; (B1 and B2) a lung CT on 12 July 2022 after six cycles of anlotinib hydrochloride combined with sintilimab; (C1 and C2) the last lung CT on 29 November 2022 showed complete remission of the primary lung tumour.

Figure 3.. Representative magnetic resonance imaging (MRI) scans of the brain of a 15-year-old male that was admitted with recurrent headaches: (A1 and A2) a brain MRI scan on 25 February 2020 before treatment with anlotinib hydrochloride combined with sintilimab showed that the maximum diameter of the metastatic lesions was 3.8 cm; (B1 and B2) a brain MRI scan on 12 July 2022 after six cycles of anlotinib hydrochloride combined with sintilimab; (C1 and C2) the most recent MRI scan on 29 November 2022 showed that the maximum diameter of the metastatic lesions was 0.9 cm (i.e. a 74% reduction after treatment) and the perifocal oedema had completely disappeared.