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June 1, 1994Antimicrobial Agents and ChemotherapyOpen Access

Novel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2',3'-didehydro-2',3'-dideoxythymidine in cell culture

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Authors

SLSimon F. LaceyResearch Triangle Park FoundationBLBrendan LarderStichting HIV Monitoring

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Lacey et al. (1994) studied this question.

synapsesocial.com/papers/6a83fa8b07bf35307a997496https://doi.org/10.1128/aac.38.6.1428
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Patterns of Intracellular Metabolism of 2′,3′-Didehydro-2′,3′-dideoxythymidine and 3′-Azido-2′,3′-dideoxythymidine, Two Potent Anti-human Immunodeficiency Virus Compounds1989 · 340 citations
  2. 2Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.1993 · 609 citations
  3. 3Activation of a beta-galactosidase recombinant provirus: application to titration of human immunodeficiency virus (HIV) and HIV-infected cells1990 · 110 citations
  4. 4Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3‘-azido-3‘-deoxythymidine.1992 · 117 citations
  5. 5Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides1993 · 368 citations