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November 1, 1988Circulation Research

Flow-dependent dilation in a resistance artery still occurs after endothelium removal.

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Why the study?

Does endothelium removal abolish flow-dependent dilation in rabbit resistance arteries?

Population

Rabbit resistance arteries in vitro

Comparison

Endothelium removal by rubbing vs Intact endothelium (baseline response)

Design

Preclinical

Authors

JBJohn A. BevanUniversity of VermontEJElizabeth H. JoyceStanford UniversityGWGeorge C. WellmanUniversity of Vermont

Discussion

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Implication

Suggests endothelium-independent flow relaxation in resistance arteries; leaves open mechanisms and human relevance.

Key Points

  • To determine whether flow-dependent vasodilation in resistance arteries depends exclusively on an intact endothelium or also involves the vascular smooth muscle.
  • Perfused tonically contracted rabbit resistance arteries in vitro with physiological saline solution to measure flow-induced active relaxation.
  • Mechanically denuded the endothelium by rubbing, confirming removal via scanning electron microscopy and absence of relaxation to 1 µM acetylcholine.
  • Intact resistance arteries exhibited a mean flow-induced relaxation of 70% upon luminal infusion.
  • Endothelial removal significantly attenuated flow-dependent relaxation from 70% to 37% (p < 0.01), demonstrating substantial residual dilation.

Structured PICO

Does endothelium removal abolish flow-dependent dilation in rabbit resistance arteries?

P
Population
Rabbit resistance arteries in vitro
I
Intervention
Endothelium removal by rubbing
C
Comparator
Intact endothelium (baseline response)
O
Outcome
Flow-dependent relaxation (dilation) in response to physiological saline solution infusionsurrogate

Flow-dependent relaxation in rabbit resistance arteries is partially independent of the endothelium, originating from both the tunica intima and media.

Cite This Study

Bevan et al. (1988) studied this question.

synapsesocial.com/papers/6a83fac4d65172829ee670c2https://doi.org/10.1161/01.res.63.5.980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reactive dilation of large coronary arteries in conscious dogs.1984 · 206 citations
  2. 2Relationship between blood flow direction and endothelial cell orientation at arterial branch sites in rabbits and mice.1981 · 217 citations
  3. 3Mechanotransducer ion channels in chick skeletal muscle: the effects of extracellular pH.1985 · 104 citations
  4. 4Shear stress and aortic histamine synthesis1978 · 54 citations
  5. 5The effect of blood flow on the surface morphology of the human endothelium1980 · 18 citations