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June 1, 1985The Journal of PhysiologyOpen Access

Mechanotransducer ion channels in chick skeletal muscle: the effects of extracellular pH.

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Population

Tissue-cultured chick pectoral muscle

Comparison

Increasing extracellular pH from 7.4 to 10.0 vs Extracellular pH 7.4

Design

Preclinical

Authors

FGF GuharayFSFrederick Sachs

Discussion

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Overview

Extracellular pH modulates the voltage and stretch sensitivity of mechanotransducer channels in chick skeletal muscle, likely via titration of a specific site with a pK of 9.1.

Structured PICO

P
Population
Tissue-cultured chick pectoral muscle
I
Intervention
Increasing extracellular pH from 7.4 to 10.0
C
Comparator
Extracellular pH 7.4
O
Outcome
Channel conductance, reversal potential, and kinetic rate constants (voltage and stretch sensitivity)surrogate

Extracellular pH modulates the voltage and stretch sensitivity of mechanotransducer channels in chick skeletal muscle, likely via titration of a specific site with a pK of 9.1.

Cite This Study

Guharay et al. (1985) studied this question.

synapsesocial.com/papers/6a7ab2558d250a4360f42b98https://doi.org/10.1113/jphysiol.1985.sp015699
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