Population
Xenopus oocytes expressing the inward rectifier K+ channel Kir2.3
Comparison
Intracellular acidification and extracellular… vs Baseline physiological pH (pH 7.4)
Design
Preclinical
Authors
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Kir2.3 pH sensors may shape excitability in cardiac acidosis; leaves open native cardiomyocyte and in vivo validation.
Kir2.3 channels possess two distinct pH sensors for intra- and extracellular acidification, which modulate the channel through different mechanisms without requiring cytosol-soluble factors.
Zhu et al. (1999) studied this question.
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