January 1, 2008Cellular Physiology and Biochemistry

Novel Insights into the Structural Basis of pH-Sensitivity in Inward Rectifier K+ Channels Kir2.3

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Population

Inward rectifier K+ channels Kir2.3

Design

Preclinical

Authors

OUOana N. UrecheFederation University RBRavshan BaltaevMayo Clinic LULiviu UrecheUniversity of Tübingen

Discussion

Member takes

Implication

May inform pH-sensitive Kir modulation in cardiac disease; leaves open human translation from animal models.

Structured PICO

Population

Inward rectifier K+ channels Kir2.3

Intervention

Engineering a cobalt coordination site and reduction/oxidation sensitivity by introduction of a cysteine (Kir2.3(H117C)) and SCAM analysis

Outcome

Structural basis of pH-sensitivity and location of Kir2.3(H117)

The study provides molecular insight into the unique pH regulation of inward rectifier channels, showing that low pH may stabilize the outer pore domain and reduce ion permeation.

Cite This Study

Ureche et al. (2008) studied this question.

synapsesocial.com/papers/6a8a570e6fc170cbc2fbe3c6 https://doi.org/10.1159/000129629

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Novel Insights into the Structural Basis of pH-Sensitivity in Inward Rectifier K+ Channels Kir2.3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Novel Insights into the Structural Basis of pH-Sensitivity in Inward Rectifier K+ Channels Kir2.3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider