Role of cyclic GMP in the mechanism of action of nitrovasodilators, endothelium-dependent agents and atrial natriuretic peptide

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Population

Cell-free preparations and tracheal smooth muscle preparations

Design

Review

Authors

Discussion

Explains nitrovasodilator efficacy in angina and HF; leaves open isoform-specific targeting for next-generation agents.

Population

Cell-free preparations and tracheal smooth muscle preparations

Intervention

Nitrovasodilators (azide, hydroxylamine, nitrite, nitroglycerin, nitroprusside), endothelium-dependent agents, and atrial natriuretic peptide

Outcome

Guanylate cyclase activation, cyclic GMP synthesis, and smooth muscle relaxationsurrogate

Nitrovasodilators induce smooth muscle relaxation by activating guanylate cyclase and increasing cyclic GMP synthesis.

Ferid Murad (1988) studied this question.

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