Microspheres formed from a new poly(β-amino ester) degrade slowly at pH 7.4 (left fluorescence microscopy image) but dissolve quickly at pH values below 6.5 (right), to release encapsulated material rapidly and quantitatively. As the pH/solubility transition occurs within the intracellular pH range, these tiny spheres hold promise as intracellular drug delivery vehicles.
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Lynn et al. (2001) studied this question.
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