January 1, 1999Journal of Vascular Research

Network Vascular Communication Initiated by Increases in Tissue Adenosine

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Structured PICO

Population

Anesthetized hamster cheek pouch (n = 25) or cremaster muscle (n = 10)

Intervention

Nitric oxide (NO) donors (10(-5) to 10(-3) M), adenosine (10(-5) to 10(-3) M), or papaverine (10(-5) to 10(-2) M) applied for 40-120 s either directly to an arteriole or into the tissue 500 microm away

Comparator

Direct vs tissue application; papaverine application

Outcome

Remote arteriolar responses (dilation)surrogate

Increases in tissue adenosine may be critical for vascular communication of metabolic demands independent of specific blood flow paths.

Discussion

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Implication

Animal data implicate tissue adenosine in remote arteriolar dilation; leaves open clinical relevance for metabolic vascular signaling in humans.

Cite This Study

Rivers et al. (1999) studied this question.

synapsesocial.com/papers/6a83faef902d1005cc4a1015 https://doi.org/10.1159/000025642

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Implication

Animal data implicate tissue adenosine in remote arteriolar dilation; leaves open clinical relevance for metabolic vascular signaling in humans.

Network Vascular Communication Initiated by Increases in Tissue Adenosine

Structured PICO

Discussion

Implication

Cite This Study

Network Vascular Communication Initiated by Increases in Tissue Adenosine

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider