Why the study?
Does nitroarginine affect local and conducted arteriolar dilations induced by methacholine in hamster cheek pouch arterioles?
Does nitroarginine affect local and conducted arteriolar dilations induced by methacholine in hamster cheek pouch arterioles?
In hamster cheek-pouch arterioles, muscarinic agonists cause two modes of dilation mediated by different mechanisms: nitric oxide for local dilation and a hyperpolarizing factor for conducted dilation.
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Does not support clinical translation of nitroarginine effects; hypothesis-generating for distinct NO-dependent local versus conducted dilation mechanisms.
Richard J. Rivers (1997) studied this question.
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