Why the study?
PDE10A upregulation had been observed in the diseased heart, but its roles in cardiovascular biology and disease were largely uncharacterized.
Population
Isolated adult mouse cardiac myocytes and fibroblasts, and mouse models of hypertrophy and heart failure
Comparison
PDE10A selective inhibitor TP-10 or global PDE10A knockout vs controls
Design
Preclinical in vitro and in vivo animal study
Authors
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PDE10A inhibition attenuates remodeling in animal HF models; hypothesis-generating, translation to patients remains open.
PDE10A inhibition attenuates pathological cardiac remodeling and dysfunction in preclinical models, suggesting it as a potential novel therapeutic target for heart failure.
Chen et al. (2019) studied this question.
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