Population
Rat aorta and kidney homogenates
Comparison
Thiopental (10-100 microg/mL) vs Basal conditions and endothelium-independent…
Design
Preclinical
Authors
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Thiopental may suppress endothelial NO production in vitro; leaves open relevance to vascular tone or anesthesia in vivo.
Thiopental inhibits endothelium-dependent relaxation and nitrite production in rat aorta, indicating an inhibitory effect on nitric oxide synthase.
Castillo et al. (1999) studied this question.
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