December 1, 1995Hypertension
Endothelin Subtype B Receptor–Mediated Calcium and Contractile Responses in Small Arteries of Hypertensive Rats
Population
Endothelium-denuded mesenteric resistance arteries from adult spontaneously hypertensive rats and…
Comparison
Endothelin subtype B receptor agonist… vs Normotensive Wistar-Kyoto rats
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Altered ETB calcium signaling in hypertensive rat vessels; hypothesis-generating for human hypertension mechanisms and therapies.
Structured PICO
P
Population
Endothelium-denuded mesenteric resistance arteries from adult spontaneously hypertensive rats and Wistar-Kyoto rats
I
Intervention
Endothelin subtype B receptor agonist sarafotoxin S6c and endothelin-1
C
Comparator
Normotensive Wistar-Kyoto rats
O
Outcome
Contractile responses (lumen diameter) and intracellular calcium ([Ca2+]i)surrogate
Endothelin subtype B receptors are present in vascular smooth muscle of small arteries and mediate vasoconstriction through intracellular calcium signaling, with blunted responses in hypertensive rats.
Cite This Study
Touyz et al. (1995) studied this question.