This review of veteran twins demonstrates a significantly higher concordance rate of schizophrenia in monozygotic compared to dizygotic twins, supporting both genetic and environmental factors in its etiology.
Supports combined genetic-environmental schizophrenia etiology; confirms classic twin-study heritability in veterans.
The authors performed a systematic diagnostic review of the records of all twin pairs with a psychotic diagnosis in the Veteran Twin Registry. They found 274 pairs of twins (313 individuals) in which one or both were "clearly" schizophrenic, a frequency of 0.98 percent. The monozygotic (MZ) concordance was 27.4 percent, the dizygotic (DZ) concordance was 4.8 percent, and the MZ/DZ ratio was 5.7. Compared with the results of a computer search, these results present a higher MZ concordance and MZ/DZ ratio. The authors also review the results of the major twin studies of schizophrenia, which indicate that both genetic and environmental factors are significant in the occurrence of schizophrenia.
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Allen et al. (1972) studied this question.
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