Cimetidine and Immunologic Response

Letters1 July 1980Cimetidine and Immunologic ResponseMICHAEL R. SIMON, M.D.MICHAEL R. SIMON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-1-152_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the recently published paper "Cimetidine as an Immunomodulator: Chronic Mucocutaneous Candidiasis as a Model" (1), the authors report that their patients with chronic mucocutaneous candidiasis developed positive delayed hypersensitivity skin tests while receiving cimetidine. In neither this paper nor in an earlier description of the same patients (2) are results of immediate hypersensitivity skin tests with candidal antigen reported. Immunologic histamine release induced by cutaneous injection of antigen may suppress the delayed hypersensitivity skin response to that antigen (3). Nine of 10 patients with chronic mucocutaneous candidiasis reported by Kirkpatrick and Smith (4) showed immediate hypersensitivity...References1. JORIZZOSAMSJEGASOTHYOLANSKY JWBA. Cimetidine as an immunomodulator: chronic mucocutaneous candidiasis as a model. Ann Intern Med. 1980;92(Part 1):192-5. LinkGoogle Scholar2. SAMSJORIZZOSNYDERMAN WJR. Chronic mucocutaneous candidiasis: immunologic studies of three generations of a single family. Am J Med. 1979;67:948-59. CrossrefMedlineGoogle Scholar3. SLAVINTENNENBAUMBECKERFEINBERGFEINBERG RJRAS. Cell transfer of delayed hypersensitivity to ragweed from atopic subjects treated with emulsified ragweed extracts. J Allergy. 1963;34:368-73. CrossrefMedlineGoogle Scholar4. KIRKPATRICKSMITH CT. Chronic mucocutaneous candidiasis: immunologic and antibiotic therapy. Ann Intern Med. 1974;80:310-20. LinkGoogle Scholar5. SIMONTUBERGENCASSIDYSILVAMAGILAVY MDJJD. Chronic mucocutaneous candidiasis clinically exacerbated by type I hypersensitivity. Clin Immunol Immunopathol. 1979;14:56-63. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Medical Center Allen Park, MI 48101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEsophageal Candidiasis as a Complication of Inhaled CorticosteroidsGeochemistry. AtmosphereLeukocyte Function in Human Allergic Disease 1 July 1980Volume 93, Issue 1_Part_1Page: 152-152KeywordsAntigensCandidiasisHistamineHypersensitivitySkin tests Issue Published: 1 July 1980 PDF DownloadLoading ...