Why the study?
Does tissue Doppler imaging detect early asymptomatic myocardial abnormalities in a dog model of Duchenne's cardiomyopathy?
Population
20 dogs, age 25+/-11 weeks, with normal conventional parameters of systolic function
Comparison
Tissue Doppler imaging (TDI) vs Conventional echocardiography
Design
Preclinical, Blinded to genotype ('without knowledge of the genotype')
Authors
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Supports TDI for preclinical DMD model detection; leaves open human translation and validation.
Does tissue Doppler imaging detect early asymptomatic myocardial abnormalities in a dog model of Duchenne's cardiomyopathy?
Tissue Doppler imaging is more sensitive than conventional echocardiography in detecting pre-clinical myocardial abnormalities in a dog model of Duchenne muscular dystrophy.
Valérie Chetboul (2004) studied this question.
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