Population
Young (9-11 wk old) Zucker lean and obese (fa/fa) rats
Comparison
Inhibition of Nox, mitochondrial respiratory… vs Zucker lean rats and uninhibited tissues
Design
Preclinical
Authors
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Identifies G6PD-NADPH as potential driver of diabetic myocardial superoxide; hypothesis-generating and requires human validation before any clinical consideration.
In a rat model of severe hyperlipidemia and hyperglycemia, Nox-derived superoxide generation in the myocardium and aorta is fueled by elevated levels of G6PD-derived NADPH before the development of overt cardiac dysfunction.
Serpillon et al. (2009) studied this question.
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