Why the study?
Does OX40 knockout prevent pressure overload-induced cardiac hypertrophy and remodeling in mice?
Does OX40 knockout prevent pressure overload-induced cardiac hypertrophy and remodeling in mice?
OX40 regulates pressure overload-induced cardiac remodeling via modulation of CD4+ T-lymphocytes, suggesting a potential novel mechanism and therapeutic target for cardiac hypertrophy.
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Hypothesis-generating for OX40 as target in pressure-overload models; requires validation before any clinical translation.
Wu et al. (2016) studied this question.
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