The C-glucosyl bond of barbaloin, a major purgative principle of aloe, was cleaved with human intestinal bacteria under anaerobic conditions, yielding aloe-emodin anthrone and aloeemodin bianthrone. Fecal flora of humans had the most potent transforming activity but those of rats and mice had less or no activity.
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Hattori et al. (1988) studied this question.