Perceived Risk of Ischemic and Bleeding Events in Acute Coronary Syndromes
Why the study?
Does objective risk assessment using the GRACE score improve risk discrimination compared to physician-estimated risk in patients with acute coronary syndrome?
Population
1542 patients with acute coronary syndrome from 58 hospitals in Australia, China, India, and Russia.
Comparison
Objective risk assessment using the Global… vs Physician-estimated risk
Design
Cohort
Follow-up
up to 6 months
Authors
Discussion
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Member takes
Implication
GRACE score may improve mortality risk discrimination over physician estimates in ACS; hypothesis-generating for prospective implementation trials.
Structured PICO
Does objective risk assessment using the GRACE score improve risk discrimination compared to physician-estimated risk in patients with acute coronary syndrome?
P
Population
1542 patients with acute coronary syndrome from 58 hospitals in Australia, China, India, and Russia.
I
Intervention
Objective risk assessment using the Global Registry of Acute Coronary Events (GRACE) score
C
Comparator
Physician-estimated risk
O
Outcome
Discrimination of risk for death, death/myocardial infarction, and bleeding events up to 6 months (measured by c statistic)hard clinical
Objective risk assessment with the GRACE score provides significantly better risk discrimination for 6-month mortality in ACS patients compared to physician intuition.
Cite This Study
Chew et al. (2013) studied this question.