Why the study?
Does KB-R7943 reduce the amplitude of delayed afterdepolarizations in rat ventricular trabeculae?
Does KB-R7943 reduce the amplitude of delayed afterdepolarizations in rat ventricular trabeculae?
Inhibition of the Na+-Ca2+ exchange current significantly reduces the amplitude of delayed afterdepolarizations, highlighting its role in triggered arrhythmias.
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Supports NCX as target for triggered activity; hypothesis-generating in animal models, human translation remains open.
Sugai et al. (2009) studied this question.
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