February 1, 1999GutOpen Access

Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised by antigliadin antibodies of patients with coeliac disease

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Population

Sera from 9 patients with active coeliac disease

Design

Preclinical

Authors

SKStanislava KrupičkováCzech Academy of Sciences LTLudmila TučkováUniversity Hospital Olomouc ZFZuzana FlegelováUniversity of Alberta

Discussion

Member takes

Implication

Hypothesis-generating for molecular mimicry in celiac disease; human validation required before any clinical relevance.

Structured PICO

Population

Sera from 9 patients with active coeliac disease

Intervention

Affinity chromatography isolation of antigliadin antibodies (AGA) and testing by competitive ELISA using 40 alpha-gliadin synthetic dodecapeptides (A1-F6)

Outcome

Characterization of antigenic structures of gliadin, enterocytes, and calreticulin recognized by AGAsurrogate

Antigliadin antibodies in coeliac disease react with similar epitope structures on gliadin and potential autoantigens on enterocytes, such as calreticulin.

Cite This Study

Krupičková et al. (1999) studied this question.

synapsesocial.com/papers/6a840544165e087ca0f2ee0f https://doi.org/10.1136/gut.44.2.168

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Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised by antigliadin antibodies of patients with coeliac disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised by antigliadin antibodies of patients with coeliac disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider