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June 5, 2010European Heart JournalOpen Access

Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload

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Population

Mice subjected to 4 weeks of ascending aortic banding

Comparison

Debanding operation (DB) vs Sham level

Design

Preclinical

Follow-up

Up to 14 days

Authors

JBJohannes L. BjørnstadISI. SjaastadSNStåle Nygård

Discussion

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Overview

Temporal collagen isoform shifts during reverse remodeling should not change practice; hypothesis-generating for ECM-targeted therapies in human pressure-overload recovery.

Structured PICO

P
Population
Mice subjected to 4 weeks of ascending aortic banding
I
Intervention
Debanding operation (DB)
C
Comparator
Sham level
O
Outcome
Alterations in myocardial gene expression and collagen subtypessurrogate

Reverse remodeling after relief of pressure overload involves a distinct temporal shift in collagen isoforms, highlighting the dynamic nature of the extracellular matrix during cardiac recovery.

Cite This Study

Bjørnstad et al. (2010) studied this question.

synapsesocial.com/papers/6a8405486b6022c7d8c51d1ahttps://doi.org/10.1093/eurheartj/ehq166
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