Effects of local anesthetics on Na+ channels containing the equine hyperkalemic periodic paralysis mutation

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Population

Rat skeletal muscle Na+ channels containing the equine hyperkalemic periodic paralysis mutation expressed in…

Comparison

Local anesthetics vs Wild-type channels and eqHPP channels without drug

Design

Preclinical

Authors

Discussion

Cautions against local anesthetic use to normalize inactivation in eqHPP; leaves open targeted therapies for clinical translation.

Population

Rat skeletal muscle Na+ channels containing the equine hyperkalemic periodic paralysis (eqHPP) mutation expressed in Xenopus oocytes

Intervention

Local anesthetics (benzocaine, lidocaine, mexiletine)

Comparator

Wild-type (WT) channels and eqHPP channels without drug

Outcome

Inactivation properties (time constants of current decay, inactivation curves, recovery from inactivation)surrogate

Local anesthetics like benzocaine, lidocaine, and mexiletine cannot fully restore normal inactivation properties in eqHPP-mutated Na+ channels.

Sah et al. (1998) studied this question.

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