Two human paramyotonia congenita mutations have opposite effects on lidocaine block of Na+ channels expressed in a mammalian cell line.
Population
Human embryonic kidney cell line expressing mutant and wild-type human skeletal muscle voltage-gated Na+…
Comparison
Lidocaine (lignocaine) vs Wild-type hSkM1 channels
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May indicate mutation-specific lidocaine sensitivity in paramyotonia; leaves open clinical translation pending human studies.
Structured PICO
P
Population
Human embryonic kidney cell line (tsA201) expressing mutant (T1313M, R1448C) and wild-type human skeletal muscle voltage-gated Na+ channel alpha-subunits (hSkM1)
I
Intervention
Lidocaine (lignocaine)
C
Comparator
Wild-type hSkM1 channels
O
Outcome
Lidocaine block characteristics (phasic block, rest block, inactivated state affinity)surrogate
Two paramyotonia congenita mutations (T1313M and R1448C) have opposite effects on lidocaine block of Na+ channels, altering phasic block through changes in affinity and kinetics, respectively.
Cite This Study
Fan et al. (1996) studied this question.