Why the study?
More than half of patients with symptoms suggestive of myocardial ischemia undergoing invasive angiography have no obstructive CAD, and a large proportion have coronary microvascular dysfunction associated with adverse cardiovascular prognosis.
Transthoracic Doppler echocardiography is a feasible and reproducible method for evaluating coronary microvascular function in patients with angina and no obstructive CAD.
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May support non-invasive microvascular assessment in angina without obstructive CAD; leaves open prospective validation before adoption.
More than half of the patients with symptoms suggestive of myocardial ischemia presenting at invasive angiography have no obstructive coronary artery disease (CAD). A large proportion of these patients have ischemia caused by coronary microvascular dysfunction, a condition associated with adverse cardiovascular prognosis. Measurement of coronary flow velocity reserve by transthoracic Doppler echocardiography is a feasible and reproducible method for the evaluation of coronary microvascular function. This review provides a practical overview of the method in a clinical setting of angina and noobstructive CAD, including technical details and prognostic significance.
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Bechsgaard et al. (2021) studied this question.
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