Why the study?
VT storm in advanced systolic heart failure carries high morbidity and mortality, but ablation with advanced imaging and mechanical circulatory support may not be available in resource-limited settings.
Does substrate-guided catheter ablation without mechanical circulatory support terminate ventricular tachycardia storm in a high-risk patient with advanced ischemic cardiomyopathy?
Does substrate-guided catheter ablation without mechanical circulatory support terminate ventricular tachycardia storm in a high-risk patient with advanced ischemic cardiomyopathy?
Substrate-guided mapping with tailored pharmacological hemodynamic support can enable successful VT ablation in select high-risk patients when mechanical circulatory support and advanced imaging are unavailable.
May support substrate-guided VT ablation without MCS in select unstable cases; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: Ventricular tachycardia (VT) storm in advanced systolic heart failure carries high morbidity and mortality. Ablation is often performed with advanced imaging and mechanical circulatory support, which may not be available in resource-limited settings. CASE SUMMARY: A 62-year-old man with ischemic cardiomyopathy (left ventricular ejection fraction: 25% to 30%) presented with recurrent monomorphic VT refractory to antiarrhythmic therapy, complicated by hemodynamic instability and multiorgan dysfunction. Mechanical circulatory support was not feasible. Substrate-guided mapping using voltage, late potentials, local abnormal ventricular activity, isochronal late activation mapping, and decrement-evoked potential mapping localized a critical isthmus in the basal posterior left ventricle. Ablation terminated VT and rendered it noninducible under monitored anesthesia care with norepinephrine and low-dose dobutamine. CONCLUSION: Functional substrate mapping with limited intra-VT mapping and tailored anesthesia enabled procedural stability and successful VT ablation. TAKE-HOME MESSAGE: Substrate-guided mapping with individualized hemodynamic support can achieve safe, effective VT ablation in resource-limited settings.
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Tran et al. (2025) studied this question.
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