Why the study?
The study was conducted to investigate clinical outcomes in patients with non-valvular atrial fibrillation compared between those with and without diabetes mellitus.
Does diabetes mellitus increase the risk of ischemic stroke, major bleeding, and heart failure in patients with non-valvular atrial fibrillation?
Population
3402 patients with non-valvular atrial fibrillation from 27 hospitals in Thailand
Comparison
Patients with diabetes mellitus vs without diabetes mellitus
Design
Prospective multicenter nationwide registry with propensity score matching
Follow-up
Average 25.74 ± 10.57 months
Authors
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DM associated with higher stroke, bleeding, and HF risks in NVAF; leaves open whether anticoagulation intensity should differ.
Does diabetes mellitus increase the risk of ischemic stroke, major bleeding, and heart failure in patients with non-valvular atrial fibrillation?
Diabetes mellitus significantly increases the risk of ischemic stroke, major bleeding, and heart failure in patients with non-valvular atrial fibrillation, though the net clinical benefit of oral anticoagulation remains favorable in this high-risk group.
Krittayaphong et al. (2021) studied this question.