Why the study?
How do drug-free platelets affect platelet aggregation in the presence of standard antiplatelet therapy?
Population
In vitro platelet models
Comparison
Introduction of different proportions of… vs Different proportions of uninhibited platelets…
Design
Preclinical
Authors
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May underlie variable antiplatelet responses in high-turnover states; leaves open clinical translation from this animal model.
How do drug-free platelets affect platelet aggregation in the presence of standard antiplatelet therapy?
Drug-free platelets can act as seeds for aggregate formation, providing a mechanistic explanation for reduced antiplatelet drug efficacy in conditions of increased platelet turnover.
Hoefer et al. (2015) studied this question.
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